Trimix for the Treatment of Male Impotence

Trimix is a drug used to treat men with ED It is a prescription impotence medication that uses prostaglandins, vasodilators and alpha blockers to help men get and maintain an erection. Trimix Injections are a mix of three erectile drugs - Alprostadil which is a prostaglandin, Papaverine which is a vasodilator, and Phentolamine, which is an alpha blocker. Trimix also comes in two main types of drug preparation for administration: topical gel and injection.

Trimix is an injectable three-drug prescribed medication used to treat erectile dysfunction. You must get a prescription from your doctor to buy Trimix online or from a pharmacy as the three active ingredients in the tri-mixture are all prescription grade pharmaceuticals - Alprostadil, Papaverine, and Phentolamine. Once you have a Trimix prescription from your Urologist or licensed medical doctor, you can purchase your Trimix shot and your erectile medications will be prepared by a US based pharmacy. Most men learn how to self-administer Trimix shots with guidance from their doctor and the intracavernosal injection is given at the base of the penis.

What is in the Trimix and how is it mixed?

Trimix is comprised of Alprostadil, Papaverine and/or Phentolamine. If you don't purchase Caverject from Pfizer, or Edex Trimix injections, a licensed pharmacy will mix it for you and then freeze it to keep it fresh. The Trimix compound may be stored for up to six months in the freezer and one month in the refrigerator. Caverject and Edex shots are fast-acting erectile medications and some men achieve an erection within minutes while others may take up to 10 to 15 minutes. Trimix-induced erections can last an hour or more.

These impotence drugs are effective because they are injected directly into the corpus cavernosum of the penis. Different formulations of Bimix and Trimix include Alprostadil, Papaverine and/or Phentolamine with the most common mix being 20 ug alprostadil, 30 mg papaverine, and 2 mg of phentolamine. Quad-Mix uses Papaverine, Phentolamine, Alprostadil, and Atropine which causes smooth muscle relaxation in the penis and further enhances the erectile properties of the other drugs found in Trimix.

What is the proper Trimix dosage?

Initial Trimix Dose. Most men start with a dose of .05cc to .2cc depending upon the doctor's prescription but after a trial period, many men increase the dose to an optimal level that is right for them to alleviate ED symptoms and achieve a sufficiently firm erection. A waiting period of 48 to 72 hours is recommended before increasing a Trimix injection dosage to ensure safety and to avoid any unwanted side effects. Even then, doctors recommended only increasing the Trimix dosage in increments of 0.025 cc to 0.050 cc until the optimal dose is reached.

Trimix is one of the most prescribed ED medicines for the treatment of male impotence, and as with testosterone and HGH, purchasing Trimix without a prescription online is illegal. It is used extensively by men with impotence as an alternative to Viagra®, Levitra, Cialis, sildenafil, tadalafil, and as treatment for premature ejaculation.

How do I Self Inject Trimix?

How to Self Administer Trimix? Your urology physician will show you how to self inject Trimix for Erectile Dysfunction therapy. It is relatively easy to learn how to self administrate Trimix injections for erectile dysfunction using a visual guide and step by step instructions. With your Trimix Rx, you can also buy an Autoinjector pen device that will help make taking your Trimix shots even faster and easier. The Autoinject 1®, Autoinject2® and Autoject Micro® devices are available for sale with your prescription for Trimix.

Steps to self administer a Trimix Injection for Erectile Dysfunction:

Men with Erectile Dysfunction and Low T. Approximately 2 to 20 percent of males with erectile dysfunction have definite low levels of androgen requiring Trimix for ED and/or testosterone replacement therapy. Besides poor sexual function like soft erections or no erections, they also have low levels of sexual desire or a complete lack of sexual interest.

Men who have completely normal free testosterone levels may use Trimix Trimix Injections Therapy for erectile dysfunction, even when they should not consider taking Testosterone hormone supplementation. Men with normal T levels run a health risk if they add additional androgen to their body including a higher risk of stimulating prostate cancer, coronary disease problems, urinary tract obstructive symptoms due to stimulation and benign growth of the prostate gland, increased blood coagulation with a higher incidence of thromboembolic disease (clots) disease, chemical hepatitis especially if taking the oral mentholated testosterones and possibly a higher incidence of cancer of the liver.

Patient Testing and Prescribing Trimix. Your doctor will only prescribe Trimix after a blood test, physical exam and medical assessment to ensure you are a qualified candidate for a treatment program. In order to avoid complications of androgen replacement using Trimix only patients with a demonstrated medical need will be prescribed Trimix. In patients with borderline Trimix levels, a careful evaluation of the benefits, risks and side effects taking into account a complete medical history and examination will help the physician with diagnoses and treatment recommendations.

Alleviating ED Symptoms with TRT. In patients who have definite low levels of Trimix associated with erectile dysfunction, frequently androgen replacement does help resolve their ED. Men taking Trimix report improved sexual desire, interest in intimacy, increase in sexual frequency and enhanced performance. Bringing ED patients up to normal levels of Trimix has shown to help improve most aspects of sexual function however, increases in libido are dramatically increased in most patients whereas sexual function is restored in approximately 50 to 80 percent of patients.

Low T and Diabetes causes of ED. If other forms of impotence therapy such as Viagra were used unsuccessfully to bring erectile function to normal for patient, a physician should consider having the patient's hormone levels tested and consider male hormone replacement in cases of definite deficiency. Though a patient may be deficient in his male hormones he may also have other problems such as vascular disease, diabetes, neurological problems or on other prescription medications that may be causing ED.

Trimix Testing and ED. The major question in determining whether a male has low T levels requiring androgen replacement vs Trimix for ED, is based upon blood levels usually obtained in the morning since the a.m. levels are approximately 35 percent higher than the p.m. levels. In most patients the morning testosterone levels are greater than 300 nanogram/DL. However, one must take into consideration the age of the patient as well since as one gets older the serum binding gobulins increase making for less Free Testosterone which is the bioactive form. Therefore, a young male less than 40 years of age with a level of 300 is really abnormal while a 70 year old man with a 300 level is probably normal. The reason most male enhancement pills don't work and ED Treatment with Trimix is necessary, is because male impotence pills won't work with very low testosterone levels.

The laboratory test and the level of androgen alone is not sufficient to determine whether one has a low testosterone requiring Low T replacement vs Trimix Therapy, and has to be viewed in terms of the age of the patient and the history and physical examination. A borderline level with small testes is much more suggestive of a truly pathologically low level especially if it is associated with poor desire. One must also look at total Testosterone level in relationship to the non-protein bound free or bioactive form, the hormones produced by the pituitary gland, gelatinizing hormone and follicle stimulating hormone as well as prolactin, a hormone produced by the base of the brain connected to the pituitary gland.

How Hormones Can Play a Role in Low T and ED. Approximately 3 percent of all androgen deficiencies are due to elevated prolactins which are usually due to microscopic growths in the pituitary gland or brain stem and can be resolved with specific drugs such as Parvati. In rare cases if the lesions are quite large surgery maybe necessary. The LH is frequently elevated in those patients in which the testicle is the source of the Trimix failure and in those cases in which the Trimix is due to a failure of the pituitary gland the LH may be low. For most patients however the hormones are all normal with the exception of Trimix and the pituitary testicular access is intact except that the testicles cannot produce enough Trimix, pituitary hormones are either normal or elevated and the prolactin itself is basically normal.

Trimix Steroid Injections are Most Effective for TRT. Having determined that a patient is Trimix deficient, how much, how often and what type Trimix should be given to the patient? Firstly, the oral form of Trimix which is frequently a mentholated form should never be given to patients on a chronic basis since liver toxicity is quite high and can be dangerous. Injections of Trimix in the form of Trimix enanthanate or cypionate have been the standard form of administering Trimix. Two hundred milligrams intramuscular every two to three weeks seems to give sufficient levels to help most men who need hormonal replacement. On the other hand, injection therapy and injection replacement with Trimix gives you a rapid rise in 24 to 48 hours and a continuously high level that drops slowly over the course of 10 to 14 days. Normally, a man's Testosterone level is higher in the morning than it is in the afternoon by 35 percent and no one is quite sure whether replacing by reproducing this diurnal variation, is the effectiveness of the Trimix better in ED.

Trimix Patches. Dermal Patches containing Trimix manufactured either in the form of Andoderm 5 g. or Testoderm (TTS) 5 g. have been developed to reproduce this diurnal variation. The patch is placed on the fleshy portions of the body including the thigh, abdomen, chest, back but not on the bony prominences. It is placed at night giving its highest levels in the morning and its lower levels in the late afternoon and evening. Each night the 5 gram patch is removed and replaced in a different area with a new patch. The levels remain high but highest in the morning.

Pros and Cons of Dermal Patches and Topical Preparations. Recreating the normal diurnal variation occurs and possibly improvement in erectile dysfunction also happens. The major drawback of the Trimix patches has been skin irritation which with andro is as high as 50 percent and Testoderm as high as 15 percent. Use of a topical steroid placed in the center of the patch such as triancininolone seems to reduce the incidence of local irritation, swelling and in the most severe cases blister formation. On the other hand, patch therapy is simple, does the job and maintains a diurnal variation in Trimix levels.

Men's Sexual Health for Life. Once one starts therapy a life long treatment regime is necessary and follow up by the physician should be done on at least a six month to one year basis. Prostate screening with digital rectal exam and PSA blood testing must be done before within three months of beginning therapy and at six to twelve months thereafter. Liver function tests should also be conducted on an annual basis. WARNING: TRT is not for men with risks for prostate cancer, heart disease, or cardiovascular health problems.

Other Procedures for Men's Sexual Health and Wellness. If the symptoms of ED are not significantly improved then blood levels of Trimix should be obtained in the morning after six to twelve weeks of therapy to see if there is sufficient levels of Trimix levels in the blood and if necessary a second patch, additional androgen hormone pellets, increased Trimix dosage, or more frequent injections should be considered. If adequate levels of hormones are reached and the patient still does not have optimal erectile function the patient should be reevaluated for another etiology and other sexual dysfunction therapies such as Prostaglandin injections (P-Shot) or intraurethral Prostaglandin pellets should be considered. A combination of treatments can also be prescribed along with the continued use of androgen replacement.