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TESTOSTERONE
ENANTHATE
DELATESTRYL
(Testosterone Enanthate Injection) provides testosterone enanthate,
a derivative of the primary endogenous androgen testosterone,
for intramuscular administration. In their active form, androgens
have a 17-beta-hydroxy group. Esterification of the 17-beta-hydroxy
group increases the duration of action of testosterone; hydrolysis
to free testosterone occurs. Each mL of sterile, colorless to
pale yellow solution provides 200 mg testosterone enanthate
in sesame oil with 5 mg chlorobutanol (chloral derivative) as
a preservative.
How
Taken - To be updated
Possible
Side Effects - To be updated
Female:
the most common side effects of androgen therapy are menstrual
irregularities; inhibition of gonadotropin secretion; and virilization,
including deepening of the voice and clitoral enlargement. When
administered to a pregnant woman, androgens can cause virilization
of external genitalia of the female fetus.
Male:
Gynecomastia, and excessive frequency and duration of penile
erections. Oligospermia may occur at high dosage.
Fluid and electrolyte disturbances: Retention of sodium,
chloride, water, potassium, calcium, and inorganic phosphates.
Warnings/Precautions
- Hypercalcemia may occur in immobilized patients and in
patients with breast cancer. If this occurs, the drug should
be discontinued. Prolonged use of high doses of androgens have
been associated with development of hepatic adenomas, carcinoma,
and peliosis hepatis, all potentially life-threatening complications.
Gynecomastia may develop and occasionally persists in patients
being treated for hypogonadism.
Cholestatic
hepatitis and jaundice may occur with 17aa androgens. The drug
should be discontinued if this occurs, which will reverse the
effects.
Drug
Interactions - Androgens may increase sensitivity to oral
anticoagulahts. In order to maintain satisfactory therapeutic
hypoprothrombinemia, dosage of the anticoagulant may need adjustment.
Storage
- Store in a cool, dry place.
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