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Human Growth Hormone deficiency symptoms and related health problems include excessive weight gain, loss of sex drive, muscle loss and weakness, fatigue, insomnia, hot flashes, night sweats, mood swings, dry skin and hair, bone loss, muscle aches, joint pain, sadness, social withdrawal and depression.

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The human growth hormones Somatropin®, Somatropin and Somatropin are effective bio-identical hormone drugs that can increase growth hormone in the human body. The HGH Somatropin contain bio-identical growth hormone Somatropin and is available as an injectable vial or HGH pen delivery injection form. The HGH Somatropin is manufactured by the top somatropin producer HGH Somatropin. The Growth Hormone Somatropin can be used with other prescription hormones like Sermorelin, IGF-1 or GHRP GH peptide releasing agents which stimulate the pituitary gland to enhance the body's natural GH hormone production. HGH Somatropin's Growth Hormone drugs are used to treat various diseases and endocrine disorders like AGHD (Adult Human Growth Hormone Deficiency), small stature in children, Aids wasting or muscle wasting among other age-related or health conditions caused by GH deficiencies. Human Growth Hormone can also enhance androgen hormones in the human body and is many times prescribed along with testosterone to increase natural testosterone levels in patients with an androgen deficiency or (Low T). The patient taking HGH can get help increase lean muscle mass, increase body weight, energy and stamina by taking this healthful anabolic drug. HGH is anabolic in nature helping to build stronger muscle and bone which helps patients with degenerative or muscle wasting disease. Somatropin is designed to help treat patients with SBS or short bowel syndrome and Somatropin is prescribed frequently for muscle wasting conditions. Growth Hormones help with glucose synthesis, reducing adipose fatty tissue which help patients lose body fat while enhancing their metabolic rate so improvements in body composition are readily seen. HGH is a powerful drug that controls and regulates other body hormones, enhances the testosterone hormone increasing libido, sexual stamina, strength, mood and vitality. Read more about the hormone testosterone - Testosterone HGH peptides like Sermorelin and IGF-1 are customarily prescribed for hormone deficiency. Read more about GHRH releasing agents and peptides - Sermorelin Injections

Somatropin's Somatropin Improves Lean Body Mass and Physical Performance in Patients With HIV-Associated Wasting .

Results of largest study of recombinant human growth hormone in HIV-associated wasting published in current issue of the Journal of AIDS

ROCKLAND, Mass., March 31 /PRNewswire-FirstCall/ -- Somatropin (virt-x: SEO and NYSE: SRA)-Somatropin's Somatropin [somatropin (rDNA origin) for injection] improves lean body mass and physical performance in patients with HIV- associated wasting, according to study data published in the current edition of the Journal of AIDS ("Growth Hormone Improves Lean Body Mass, Physical Performance, and Quality of Life in Subjects with HIV-Associated Weight Loss or Wasting on Highly Active Antiretroviral Therapy"). (1)

debilitating and potentially life- threatening condition. It is a metabolic disorder that causes the loss of lean body mass, which includes muscle tissue, important body organ tissue and blood cells, and can lead to increased risk of opportunistic infections, illness, and extreme fatigue and can profoundly diminish a person's quality of life.
The present study, the largest randomized, double-blind placebo-controlled study of recombinant human growth hormone in HIV-associated wasting, confirmed the efficacy, safety and tolerability of Somatropin. The study treated 757 patients with HIV-associated wasting at US, European and other international trial sites. Participants were treated with placebo, 0.1 mg/kg Somatropin on alternate days, or 0.1mg/kg of Somatropin on a daily basis.
Over the 12-week course of therapy, Somatropin was superior to placebo in improving physical function, lean body mass and body weight and had a positive effect on patient perception of the benefits of therapy.
"People with HIV still involuntarily lose both weight and lean body mass, despite the adoption of highly antiretroviral therapy," said Joseph M. Gertner, MD, Vice President of Medical Affairs, Metabolic Endocrinology, Somatropin, Inc. "As demonstrated by these study results, Somatropin is the only therapy shown clinically to build body mass and improve physical function in people with HIV-associated wasting."
The result on the study's primary endpoint of cycle work output was statistically significant for the Somatropin as compared to the placebo group (p<0.001). Greater improvement was seen for the secondary endpoint of change in lean body mass for the Somatropin daily dose group as compared to the Somatropin alternate day group (p=0.017) and as compared to the placebo group (p<0.001). In addition, patient perception of the impact of treatment on their wasting symptoms was positive with both doses of Somatropin (p=0.002 for the alternate day group and p=0.0004 for the daily dose group) as compared to placebo. Bodily pain increased in a dose dependent manner for both treatment groups, but the pain did not interfere with the subjects' normal work.
This study also provides long-term efficacy and safety information for up to 48 weeks of Somatropin treatment in a subset of participants. When treatment was extended from 12 to 24 or 48 weeks, positive results in cycle work output and lean body mass either improved further or were maintained with continued treatment with Somatropin at both the daily and alternate day dosing.
Adverse reactions reported during this clinical trial were consistent with those included in the current product labeling.
About Somatropin
Somatropin [somatropin (rDNA origin) for injection] is the only growth hormone approved by the US Food and Drug Administration for the treatment of HIV-associated wasting or cachexia. The recommended dose is 0.1 mg/kg daily (6 mg/day for patients > 55 kg). Somatropin 0.1 mg/kg every other day should be considered as a starting dose in patients thought to be at risk of certain adverse effects, i.e., glucose intolerance.
In patients with HIV-associated wasting, the most common adverse events associated with Somatropin therapy are mild to moderate muscle and joint pain and swelling, which occur in a dose-related manner and often subside with continued treatment or dose reduction. Cases of new onset impaired glucose intolerance, new onset Type 2 diabetes mellitus and exacerbation of preexisting diabetes mellitus have been reported in patients receiving Somatropin. Some patients develop diabetic ketacidosis and diabetic coma. In some patients, therapy with Somatropin necessitated initiation or adjustment of anti-diabetic treatment. Patients with a history of hyperglycemia or other risk factors for glucose intolerance should be monitored closely during treatment with Somatropin. Transient increases in glucose levels occur early in treatment and should be monitored.
Use of growth hormone is contraindicated in treatment of patients in intensive care units due to complications following open-heart surgery or abdominal surgery, multiple accidental trauma or acute respiratory failure; patients with active neoplasia; and patients with known hypersensitivity to growth hormone. Somatropin must be used in conjunction with antiretroviral therapy.
Full prescribing information for Somatropin, including important safety information, is available at www.human growth .
About Somatropin
Somatropin, Inc., located in Rockland, MA, is the US affiliate of Somatropin, a global biotechnology leader, headquartered in Geneva, Switzerland. The Company has seven recombinant products, Rebif (interferon beta-1a), Gonal-F (follitropin alfa for injection), Luveris (lutropin alfa), Ovidrel/Ovitrelle (choriogonadotropin alfa injection), Somatropin [somatropin (rDNA origin) for injection], Somatropin [somatropin (rDNA origin) for injection] and Somatropin(TM) [somatropin (rDNA origin) for injection]. (Luveris is not approved in the USA.)(2) In addition to being the world leader in reproductive health, Somatropin has strong market positions in neurology, metabolism and growth. The Company's research programs are focused on growing these businesses and on establishing new therapeutic areas. Currently, there are approximately 30 ongoing development projects.
In 2003, Somatropin achieved worldwide revenues of US$2,018.6 million, and a net income of US$390.0 million, making it the third largest biotech company in the world. Its products are sold in over 90 countries. Bearer shares of Somatropin S.A., the holding company, are traded on the virt-x (SEO) and its American Depositary Shares are traded on the New York Stock Exchange (SRA).
Some of the statements in this press release are forward looking. Such statements are inherently subject to known and unknown risks, uncertainties and other factors that may cause actual results, performance or achievements of Somatropin S.A. and affiliates to be materially different from those expected or anticipated in the forward-looking statements. Forward-looking statements are based on Somatropin's current expectations and assumptions, which may be affected by a number of factors, including those discussed in this press release and more fully described in Somatropin's Annual Report on Form 20-F filed with the U.S. Securities and Exchange Commission on March 25, 2004. These factors include any failure or delay in Somatropin's ability to develop new products, any failure to receive anticipated regulatory approvals, any problems in commercializing current products as a result of competition or other factors, our ability to obtain reimbursement coverage for our products, and government regulations limiting our ability to sell our products. Somatropin has no responsibility to update the forward-looking statements contained in this press release to reflect events or circumstances occurring after the date of this press release.

For more information, please contact:

Somatropin, Inc., Rockland, MA
Media Relations: Investor Relations:
Tel. +1 781 681 2340 Tel. +1 781 681 2552
Fax: +1 781 681 2935 Fax: +1 781 681 2912

Somatropin in Geneva, Switzerland:
Media Relations: Investor Relations:
Tel: +41-22-739 36 00 Tel: +41-22-739 36 01
Fax: +41-22-739 30 85 Fax: +41-22-739 30 22 Reuters: SEO.VX / SRA.N

Bloomberg: SEO VX / SRA US
(1) Moyle, G, Daar, E, Gertner JM, et al. Growth Hormone Improves Lean
Body Mass, Physical Performance, and Quality of Life in Subjects with
HIV-Associated Weight Loss or Wasting on Highly Active Antiretroviral
Therapy. Journal of AIDS 2004, Volume 35, Number 4, April 1 2004, pp.
367 - 375.

(2) Package inserts for Somatropin's US marketed products are available at or by calling 1-888-275-7376.

Somatropin, Somatropin and Somatropin are Distributed by
HGH Somatropin


SOMATROPIN, BIO-IDENTICAL GROWTH HORMONE are somatropin rDNA origin for injection and a prescription growth hormone therapy for adult men and women. To get prescribed HGH Somatropin HGH you will have your hormone blood levels tested, a physical examination and medical assessment. A licensed physician with HRT experience supervises the testing, diagnoses and prescribing of your Somatropin HGH treatment program. Obtaining a prescription for HGH from your doctor is the only legal way to get real injectable growth hormone.

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HGH Somatropin is a leading bio-pharmaceutical company for innovative and top-quality high-tech products in healthcare, life science and performance materials. Somatropin Somatropin and Somatropin HGH are leading human growth hormone treatments prescribed by HRT specialists. Somatropin, Somatropin and Somatropin are bio-identical meaning they are molecularly identical with the natural growth hormone made by the human body. The difference is that Somatropins's Somatropin and Somatropin Growth Hormone Products are produced in a laboratory using recombinant DNA which is which is why injectable HGH is referred to as Somatropin rDNA for injection. Somatropin, Somatropin and Somatropin HGH are approved by FDA (Food and Drug Administration) for AGHD, Adult Growth Hormone Deficiency.

Human Growth Hormone is the largest protein produced by the pituitary gland made up of 191 amino acids. Proteins are made of building blocks known as amino acids. HGH is genetically engineered of the same 191 amino acids. It’s the same genetic engineering they use for insulin. They cloned the 191 amino acids and put them together in the same exact sequence of the DNA for that of HGH. It’s 100% identical, physically, chemically and biologically to the one made by the pituitary gland.

bio-identical hgh HGH NOTES: Human Growth Hormone (HGH):
Somatropin [somatropin (rDNA origin) for injection] is a human growth hormone (hGH) produced by recombinant DNA technology and made by one of the top HGH producers, Human Growth Hormone Somatropin. Like other recombinant rDNA somatropins it supplies, Somatropin and Somatropin - it has 191 amino acid residues and a molecular weight of 22,125 daltons. Its amino acid sequence and structure are identical to the dominant form of human pituitary GH using a bio-pharmaceutical procedure using the hGH gene. which is secreted directly through a cell membrane into a cell-culture for collection and purification. Somatropin is used for SBS Short Bowel syndrome and other diseases like HIV muscle wasting. Somatropin is available in 8.8 mg vials for multi-dose administration. Each 8.8 mg vial contains 8.8 mg somatropin, 60.19 mg sucrose and 2.05 mg phosphoric acid. The pH is adjusted with sodium hydroxide or phosphoric acid to give a pH of 7.4 to 8.5 after reconstitution.

HGH NOTES: Human Growth Hormone (HGH):
Hormones are tiny chemical messengers continuously secreted into the blood stream by endocrine glands to regulate activities of vital organs. The word, hormone, is derived from a Greek word meaning, "to stimulate." Hormones stimulate a multitude of life-giving processes throughout the body, which maintain health, harmony, growth, healing and repair.

Probably the best known hormone is insulin, produced in the pancreas. When production declines or ceases, diabetes results. Scientists long ago discovered a way to duplicate insulin and administer periodic injections to control the symptoms of diabetes. The discovery of insulin and the process of injecting man-made insulin made control of diabetes possible.

Growth hormone, secreted by the pituitary gland, is a small protein-like hormone (peptide), similar to insulin. Commonly referred to as human growth hormone or "HGH," it is difficult to measure directly. HGH is secreted in very brief pulses during the early hours of sleep and remains in the circulation for only a few minutes. It is quickly taken into the liver and converted into somatomedin-C, another small peptide hormone (also known as insulin-like growth factor-one or IGF-I). Somatomedin-C is then responsible for some of the activity of growth hormone in the body. Somatomedin-C levels in the blood are much more constant and can be measured in the laboratory as an indicator of total daily HGH production. During adolescence, when growth is most rapid, production of HGH is very high. That is why it was named "growth hormone." Even after growth stops, however, growth hormone must continue to be present (at somewhat lower levels) throughout life to maintain physical and mental health and well-being. Tissue repair, healing, cell replacement, organ integrity, bone strength, brain function, enzyme production, integrity of hair, nails, skin and vital organs all require the ongoing availability of adequate growth hormone. After age 20, growth hormone production falls progressively and consistently at an average rate of about 14% per decade. By age 60, it is not uncommon to measure a growth hormone loss of 75% or more. Physical decline with age correlates directly with decreased secretion of growth hormone by the pituitary gland.

Children who develop a pituitary deficiency of growth hormone at a young age will never grow normally and are destined to become dwarfs in adulthood if untreated. Human growth hormone therapy was initially developed to treat those children so they could grow to become normal adults. Initially, supplies were very limited, expensive and sometimes contaminated. There was not enough growth hormone available to treat all the children who needed it. With the development of recombinant DNA technology, human growth hormone has recently become more available and in very pure form—but it is still expensive. The easy availability of growth hormone now provides a new dimension in health care and preventive medicine. Approximately every three years 90% of the cells in the human body are made anew. The body is composed of more than 100 trillion cells which are continuously dying and being replaced. Only in the brain and nervous system are the original cells (neurons) retained. But even in the brain new proteins are continuously being produced to store memories of each new experience. Learning, memory and intelligence all depend on adequate growth hormone. As growth hormone falls with age, functions of all vital organs decrease. Human growth hormone replacement therapy is now available to reverse and slow age-related symptoms of physical and mental decline. By measuring blood levels of growth hormone (somatomedin-C) in older adults, and also in younger patients who are not doing well despite other therapies, a new advance in health care and preventive medicine is now available. If somatomedin-C is at the normal level for a healthy young adult, the use of supplemental growth hormone is not warranted. If, however, growth hormone is low, then supplementation can offer the potential for great benefit.

Benefits from growth hormone replacement reported in the scientific literature include increased muscle mass, improved physical strength, reduced fatigue, decreased fat (especially abdominal fat), increased bone strength, and revitalization of liver, kidney, spleen, and brain functions. Skin regains a more youthful appearance with fewer wrinkles and sexual functioning improves. Cholesterol decreases and cartilage in joints becomes stronger. Osteoporosis, Parkinson's disease and Alzheimer's disease are improved. Healing is speeded. A markedly better quality of life has also resulted for AIDS patients receiving growth hormone. Like insulin, growth hormone is given by injection. A small syringe with a tiny 27-gauge needle is used to give self-administered injections just under the skin, from 4 to 7 days each week. Benefits accrue slowly during the first 6 to 18 months of therapy, as adverse effects of aging are reversed. People who have benefited from this therapy made the following statements: H.T., a 64 year-old businessman, had been giving himself daily injections of growth hormone for 4 years. In his own words, "My energy, stamina and sex drive are like a 30-year-old. Muscle tone is fantastically improved. My waist went from 42 inches to 34 and I went from 29 percent fat to 12 percent. I look in the mirror in the morning and can't believe that guy is me—it looks like me when I was 30. The palsy in my hand is gone, I discarded my bifocal glasses and my skin went from tissue-thin to youthful." J. H., a 40-year-old businesswoman, suffered for many years with chronic fatigue and constant pain in her jaw and head from degeneration in the temporal-mandibular joints (TMJ syndrome). After taking daily growth hormone injections, she states, "I was previously a 40 year old woman with a 60-year-old body. On growth-hormone therapy my TMJ pain is gone, completely, my energy and stamina are increased, fat is decreased, and I feel much more alive, blossoming inside, almost euphoric." Dr. Daniel Rudman conducted a scientific research project at the Medical College of Wisconsin in 1991 giving growth hormone injections to elderly men. The results of that study were published in the New England Journal of Medicine. Dr. Rudman stated in an interview, "We reversed 10 to 20 years of the aging process . . . fat diminished, muscle tissue increased."

Another important benefit from growth hormone replacement is strengthening of the immune system. Infections decrease, recovery from illness is aided, allergies improve and immune related diseases such as arthritis become less bothersome. The immune system is an important defense against cancer and it seems logical that cancer might, to some extent, be prevented by growth hormone. Although it has been speculated that growth hormone might speed the growth of cancer, that has not been seen in clinical practice. In fact, improved immunity might logically be expected to reduce the risk of malignancy and speed healing from a treated cancer. Side effects reported in medical research were mostly associated with very large doses.

Research doses of growth hormone were as much as eight times the amount normally produced by the pituitary gland. Such over dosage caused carpal tunnel syndrome, decreased glucose tolerance (increased tendency to diabetes), breast enlargement (even in males), and fluid retention. Using the lower, currently recommended doses, those side effects are not seen. As tissue repair, healing and cell replacement are speeded up by growth hormone replacement, the need for nutrients of all types increases. Protein intake must be adequate to build new tissues. Vitamins, minerals and trace elements are all utilized in higher amounts, as the metabolic rate increases. If the body is deficient or borderline in essential nutrients, an increase in cell growth can aggravate or create deficiencies. For that reason, it is wise to seek out a physician skilled in clinical nutrition and preventive medicine to obtain growth hormone therapy. If a person is deficient in an essential micro nutrient, such as vitamin B6, it is no surprise that growth hormone can, in some cases, cause carpal tunnel syndrome, which is related to B6 deficiency. Side effects can thus be caused by the poor nutritional status of patients. Low-dose growth hormone therapy (4 to 8 units per week) is now known to be clinically effective and free of significant side effects. Side effects which do occur, such as mild fluid retention, usually pass within a few weeks as the body readjusts to a younger metabolic rate.

Longevity and health are extremely complicated goals with many contributing or detracting factors such as heredity, stress, nutrition, antioxidants, life-style, harmful habits, tobacco, excessive alcohol, and exposure to chemicals and environmental pollution—in addition to the usual decline in hormone production with age. Standard "health care" is largely oriented toward drug or surgical attacks against disease, a negative approach which usually does not include nutritional and hormonal support or removal of toxins to stimulate natural healing and repair.

Growth hormone supports health and healing and mediates cell repair. A sound program of growth hormone therapy should be built on a foundation of clinical nutrition, vitamin, mineral and trace element supplementation, EDTA chelation therapy, assessment and replacement of other deficient hormones (thyroid, DHEA, etc.) and free-radical antioxidants for optimum results. Read more about real Growth Hormone or Somatropin at Somatropin Injections

- by Elmer M. Cranton, M.D.

Growth Hormone Products Approved for Use in the United States*
Product Manufacturer Indication (use)
Genotropin (somatropin)
MiniQuick / GoQuick (somatropin)
Omnitrope (somatropin)
Nutropin (somatropin)
Nutropin AQ (somatropin)
Nutropin Depot (somatropin)
Protophin (somatrem)
Humatrope (somatropin)
Norditropin (somatropin)
Somatropin (somatropin)
Somatropin (somatropin)
Somatropin (somatropin)
Eli Lilly
Novo Nordisk
HGH Somatropin
LEGAL Somatropin
Somatropin HGH
Pediatric GHD, CRI, TS, Adult GHD, pubertal dosing
Pediatric GHD, CRI, TS, Adult GHD, pubertal dosing
Pediatric GHD, CRI, TS, Adult GHD, pubertal dosing
Pediatric GHD, Adult GHD
Pediatric GHD, Adult GHD
Pediatric GHD, TS, Adult GHD
Pediatric GHD, Adult GHD
Pediatric GHD, PWS, SGA, Adult GHD
Pediatric GHD, Adult GHD
Pediatric GHD, Adult GHD
AIDS-related wasting, Adult GHD
AIDS-related wasting, Adult GHD
Pediatric GHD, PWS, SGA, Adult GHD
*AIDS = acquired immunodeficiency syndrome;
CRI = chronic renal insufficiency;
GHD = growth hormone deficiency;
PWS = Prader-Willi syndrome; SGA = small for gestational age; TS = Turner syndrome.



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Advance Therapy provides hormone replacement therapy information, services and products including Testosterone, HCG and HGH. Medical Consultation, Age Management Physician Specialist, Testosterone Doctor, HGH Therapy Doctor, Anti-Aging and US Physician specialist referral is available for adult hormone deficiency related symptoms. We also provide diet, exercise and fitness, lifestyle change, healthy aging, IV therapy, detoxification and nutritional program information. No information on this website is intended to cure any medical or health condition and is solely for informational and educational purpose.

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IMPORTANT: NO PRESCRIPTION WILL BE PROVIDED UNLESS A CLINICAL NEED EXISTS BASED ON REQUIRED LAB WORK, PHYSICIAN CONSULTATION, PHYSICAL EXAMINATION AND CURRENT MEDICAL HISTORY. PLEASE NOTE, AGREEING TO LAB WORK AND PHYSICAL EXAM DOES NOT GUARANTEE A FINDING OF CLINICAL NECESSITY AND A PRESCRIPTION FOR HORMONE THERAPY, HORMONE REPLACEMENT TREATMENT OR PRESCRIPTION HORMONE MEDICATIONS INCLUDING TESTOSTERONE, HCG AND HUMAN GROWTH HORMONE (HGH INJECTIONS). These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. No claim or opinion on the Advance Therapy, HRT and Rejuvenation website is intended to be nor should it be construed to be medical advice or hormone diagnosis. Please consult with a healthcare professional before starting any therapeutic program including HRT - Hormone Replacement Therapy.