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Gene Therapy Health News

New medical techniques for delivering genes and stem cells can help treat patients.


Gene Therapy for the Treatment of Disease

Gene Therapy is the therapeutic delivery of nucleic acid polymers into a patient's cells as a drug to treat disease. Gene therapy is a pioneering medical field working on ways to correct a genetic problem at its source. The polymers used in treatment are either expressed as proteins, interfere with protein expression, or possibly correct genetic mutations. The most common form of gene therapy uses DNA that encodes a functional therapeutic gene to replace a mutated broken gene. The gene polymer molecule is packaged within a vector which carries the molecule inside cells.

Gene Therapy Cell Types

Somatic Cells and Germline (germ cells) are the two types of cells used in cell therapy. In somatic cell gene therapy (SCGT), a tailored approach to treating a single gene disorder for a specific patient is used. The treatment is not heritable, it does not effect children in following generations. Somatic cell therapies are similar to stem cell treatments. Therapeutic genes are transferred into cells other than a gamete, germ cell, gametocyte or undifferentiated stem cell. Somatic gene therapy is in continuing clinical research in which therapeutic DNA is used to treat disease. Patients with single gene disorders are good candidates for somatic cell therapy using therapeutic DNA.

In germline gene therapy (GGT), germ cells known as sperm or eggs are modified by the introduction of functional genes into their genomes. Modifying a germ cell known as human genetic modification causes all the organism's cells to contain the new modified gene making this type of gene therapy heritable and passed on to later generations.

How Gene Cells are delivered?

The delivery of DNA into targeted cells are accomplished using to main methods, nanoparticles (vectors) and naked DNA. The same conceptual science used to produce somatropin or recombinant growth hormone is used in gene therapy. Recombinant viruses called biological nanoparticles or viral vectors are used as well as non-viral methods using DNA complexes.

Challenges with gene therapy are the long term vs short term effects of treatment. In order to become a more permanent cure for a health condition or disease, the therapeutic DNA introduced into target cells must remain functional for the long term. In addition , the targeted cells containing the therapeutic DNA must remain stable. One of the biggest challenges is with integrating therapeutic DNA into the cell genome. The rapidly dividing nature of cells can work against achieving long-term benefits and subsequently, patients require multiple or ongoing treatments.

Stem Cell Therapy for Treating Health Conditions and Disease

Stem cell therapy is the use of therapeutic stem cells to treat or prevent a disease or health condition. Bone marrow transplants are the most common form of stem cell therapy. Another common stem cell treatment uses stem cells derived from umbilical cord blood. Medical research is developing various sources for stem cells in order to apply stem cell treatments to neurodegenerative diseases, joint and muscle injury, deep tissue and tendon repair and many other health conditions. Stem cell therapy is used along with HGH injections to treat many sports injuries and to help induce faster wound healing.

With the ability of scientists to isolate and culture embryonic stem cells, and with scientists' growing ability to create stem cells using somatic cell nuclear transfer and techniques to create induced pluripotent stem cells, new treatments are on the horizon. Treatments based on transplant of stored umbilical cord blood including prolactin, FSH and LH (luteinizing hormone) may be used to help diagnose pituitary gland dysfunction and decreased pituitary hormones clinically known as hypopituitarism.

Types of Stem Cells and Sources of Stem Cells used for Therapy

Stem cells are the foundation for every organ and tissue in the human body. There are many different types of stem cells that are formed at different times. Stem cells include embryonic stem cells that exist at the earliest stages of development and types of tissue-specific stem cells that appear during fetal development and remain in our bodies throughout life. Those that remain well into adulthood are known as adult stem cells. All stem cells can self-renew or duplicate and can also differentiate by developing into more specialized cells. The types of stem cells used in research and treatments are as follows:

  • Embryonic stem cells (pluripotent)
  • Tissue-specific stem cells (adult or somatic)
  • Mesenchymal stem cells (stromal cells)
  • Induced pluripotent stem cells (iPS cells)
These stems cell have either of two characteristics Pluripotent (IPS) or Multipotent.
  • Pluripotent stem cells can differentiate to many types of cells in the body.
  • Multipotent stem cells can differentiate to only a small number of different cell types.

Stem cell therapy as a means of tissue regeneration uses adult-derived mesenchymal stem cells to treat injuries or defects affecting bone, cartilage, ligaments and/or tendons. There are two main categories of stem cells used for treatments: allogeneic stem cells derived from a genetically different donor within the same species and autologous mesenchymal stem cells, derived from the patient prior to use in various treatments. A third category, xenogenic stem cells, or stem cells derived from different species, are used primarily for research purposes, especially for human treatments. Bio-tech scientists have learned to make certain specialized cell types through a multi-step processes using pluripotent stem cells. Using embryonic stem cells or induced pluripotent stem (iPS), make possible the development of cells that have the potential to form all the different cell types in the body.

The first iPS cells were produced by using viruses to insert extra copies of genes into tissue-specific cells.

Most stem cells intended for regenerative therapy are generally isolated either from the patient's bone marrow or from adipose tissue, for example belly fat. Mesenchymal stem cells can differentiate into the cells that make up bone, cartilage, tendons, and ligaments, as well as muscle, neural and other progenitor tissues. Mesenchymal stem cells have been the main type of stem cells studied in the treatment of diseases affecting these tissues. The number of stem cells transplanted into damaged tissue may alter efficacy of treatment. Accordingly, stem cells derived from bone marrow aspirates, for instance, are cultured in specialized laboratories for expansion to millions of cells. Although adipose-derived tissue also requires processing prior to use, the culturing methodology for adipose-derived stem cells is not as extensive as that for bone marrow-derived cells. While it is thought that bone-marrow derived stem cells are preferred for bone, cartilage, ligament, and tendon repair, others believe that the less challenging collection techniques and the multi-cellular microenvironment already present in adipose-derived stem cell fractions make the latter the preferred source for autologous transplantation. New sources of mesenchymal stem cells are currently being researched, including stem cells present in the skin and dermis which are of interest because of the ease at which they can be harvested with minimal risk to the animal. Hematopoetic stem cells (blood) have also been discovered to be travelling in the blood stream and possess equal differentiating ability as other mesenchymal stem cells, again with a very non-invasive harvesting technique. There has been more recent interest in the use of extra embryonic mesenchymal stem cells. Research is currently underway to examine the differentiating capabilities of stem cells found in the umbilical cord, yolk sac and placenta of different animals. These stem cells are thought to have more differentiating ability than their adult counterparts, including the ability to more readily form tissues of endodermal and ectodermal origin. Stem cells for treatment of kidney and liver disease is now being pioneered.

Diseases for which stem cell treatments have been shown to be highly beneficial are hematopoietic or blood stem cell transplantation, bone marrow transplantation, immune system disorders and to rebuild the blood system after cancer treatments. Grafting of stem cells helps treat bone, skin and corneal eye injuries and diseases that implants tissues comprised of stem cells and helps foster the healing process. These stem cell procedures are widely accepted as safe and effective by the medical community. Additional health conditions for which doctors are finding stem cell and growth hormone factors useful are stem cell treatments for COPD, Degenerative Heart Disease, ALS, MLS, Herpes, Erectile Dysfunction, Renal Kidney Disease, Cartilage Repair, Shoulder Replacement, Rotator Cuff Surgery, Hip Surgery, Joint Pain and Injury, Wrist and Elbow injuries, Shoulder Surgery, Ligament Tear, Meniscus Tear, Knee Surgery, ACL and MCL injuries.

HGH Injections and Stem Cells used for Anti-Aging Therapy

Stem Cell Transplantation is a clinically tested method of helping the body's cells, tissues and organs remain healthier for longer. The process of infusing or directly injecting Pluripotent Human Stem Cells into the body for the treatment of medical conditions and injuries is an important option surgeons consider when treating patients. Procedures that require repair of damaged or infected cells are replaced with new healthy cells that differentiate, proliferate and serve to repair the damage caused by injured tissue cells. The growth factors in human growth hormone help to repair injury and foster faster healing.


Human Growth Hormone or Somatropin injections should only be used under close medical supervision. To buy HGH legally and safely, you must have a valid prescription from your doctor. The article above highlights the benefits of using and purchasing growth hormone with a prescription or from trusted sources that specialize in selling approved, quality hormone injections and steroid drugs used for hormone replacement online. It is not recommended that you buy HGH injections from untrusted sources especially from overseas countries where the quality of the HGH you are buying cannot be verified. The FDA does an excellent job of providing product safety guidelines and information and has done much to protect consumers from buying and using fake or illicit somatropin injectables that could potentially harm patients.Always confer with a licensed medical professional before taking hormone drugs like somatropin, HCG or testosterone. Get a blood test and physical examination to see if you are a good candidate for hormone replacement therapy using Human Growth Hormone. Enroll in an experienced, licensed physician's HRT program or HGH therapy program so your treatment results can be properly monitored and dosages accurately prescribed. The lab testing information provided on our website should not be used during any medical emergency or for the diagnosis or treatment of any medical health condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical or endocrine conditions.


 

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Hormone Health Related Topics

What is Male Erectile Dysfunction or Impotence? Read more about treating ED - Erectile Dysfunction

When Should Testosterone be Used to Treat Erectile Dysfunction:
Safety vs. Effectiveness of Testosterone Treatments for ED?

Using HGH Injections for the Treatment of Hormone Imbalance :
HGH Uses, Effectiveness and Safety and Growth Hormone Therapy alternative Sermorelin Acetate Injections HGH Peptide - Buy Sermorelin Online

Testosterone Supplementation is Used to treat Andropause or Low T Levels:
Testosterone Therapy for Low T and ED Therapies for men with Sexual Dysfunction Erectile Dysfunction Therapies for Men

Hormone Treatment for Healthy Aging and Longevity. Read more about HRT for healthy aging...

Hormone Deficiency Symptoms

• Decrease in sex drive
• Lack of energy
• Decrease in strength
• Decreased endurance
• Lost height
• Depression
• Weaker Erections
• Low energy after eating
• Decreased productivity

Hormone Replacement Benefits

Increases in lean muscle
Enhances sex drive
Improves memory
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Improves endurance
Increases energy
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Reduces body fat
Lowers cholesterol
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Eliminates cellulite
Reduces muscle wasting
Improves kidney function
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Increases bone density
Reduces stress levels

US Dietary Guidelines

Nutrition and Your Health: Dietary Guidelines for Americans is published jointly every 5 years by the Department of Health and Human Services (HHS) and the Department of Agriculture (USDA).

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Advance Therapy provides hormone replacement therapy information, services and products including Testosterone, HCG and HGH. Medical Consultation, Age Management Physician Specialist, Testosterone Doctor, HGH Therapy Doctor, Anti-Aging and US Physician specialist referral is available for adult hormone deficiency related symptoms. We also provide diet, exercise and fitness, lifestyle change, healthy aging, IV therapy, detoxification and nutritional program information. No information on this website is intended to cure any medical or health condition and is solely for informational and educational purpose.

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